Therapeutic Drug Monitoring in Neonates: A Trialist’s Handbook for Safe, Precise Dosing
Therapeutic Drug Monitoring in Neonates: A Trialist’s Handbook for Safe, Precise Dosing Therapeutic Drug Monitoring in Neonates: Designing Trials for Safe and Precise Dosing Why Therapeutic Drug Monitoring (TDM) Is Essential in Neonatal Trials Neonates—especially preterm infants—present the steepest pharmacokinetic (PK) gradients in human development. Glomerular filtration increases several‑fold in weeks, hepatic enzyme systems switch…