Tag: clinical trial methodologies

Crossover Trials in Clinical Research: Design, Methodology, and Best Practices

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Crossover Trials in Clinical Research: Design, Methodology, and Best Practices Comprehensive Overview of Crossover Trials in Clinical Research Crossover trials are a distinctive clinical study design where participants receive multiple interventions sequentially, serving as their own control. By minimizing inter-subject variability, crossover designs enhance statistical efficiency and reduce required sample sizes, making them particularly attractive…

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Clinical Trial Design and Protocol Development, Crossover Trials

Single-Arm Trials: Design, Applications, and Best Practices in Clinical Research

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Single-Arm Trials: Design, Applications, and Best Practices in Clinical Research Comprehensive Overview of Single-Arm Trials in Clinical Research Single-arm trials (SATs) offer a pragmatic design for evaluating the efficacy and safety of interventions when randomized controls are impractical, unethical, or infeasible. Especially prominent in oncology, rare diseases, and early-phase drug development, single-arm designs enable rapid…

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Clinical Trial Design and Protocol Development, Single-Arm Trials