Intra-Cluster Correlation and Sample Size Adjustments – Clinical Trial Design and Protocol Development
Intra-Cluster Correlation and Sample Size Adjustments – Clinical Trial Design and Protocol Development “Adjustments to Sample Size and Intra-Cluster Correlation” Introduction to Intra-Cluster Correlation In clinical studies, researchers often collect data from subjects who are naturally grouped or ‘clustered’ together. Examples of such clusters include families, hospitals, or geographical locations. The correlation of responses within…