Sample Size Re-Estimation in Rare Disease Trials: Adaptive Approaches
Sample Size Re-Estimation in Rare Disease Trials: Adaptive Approaches Optimizing Sample Sizes in Rare Disease Trials through Adaptive Re-Estimation Introduction: The Need for Sample Size Flexibility in Rare Trials Designing adequately powered clinical trials in the context of rare and ultra-rare diseases is inherently difficult due to the limited patient population and variability in disease…
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