Dose-Finding Studies in Targeted Therapies
Dose-Finding Studies in Targeted Therapies Optimizing Dose-Finding Studies in Targeted Oncology Therapies Introduction to Dose-Finding in Targeted Therapies Dose-finding studies are the cornerstone of early-phase clinical development in targeted oncology therapies. Unlike traditional cytotoxic agents, where the maximum tolerated dose (MTD) often correlates with efficacy, targeted therapies may achieve optimal activity at lower doses—defined as…